个人简介

刘睿，男，博士，食品科技学院教授、博士生导师，武汉市“黄鹤英才”。农业农村部蜂产品质量安全控制重点实验室学术委员会委员，中国养蜂学会副理事长、湖北省养蜂学会常务副理事长、武汉市现代都市农业产业技术体系——岗位专家、武汉市蜂产品质量工程控制技术研究中心主任、湖北省校企共建枸杞研发中心主任。湖北省科技厅专家库高端专家，国家自然科学基金评审专家。主要在“食品功能因子与营养健康”、“蜂产品科学”和“特色农副产品精深加工与综合利用”领域开展研究，包括：1.基于代谢组学技术与合成生物学思路研究益生菌对蜂产品的转化与增效机制。2.聚焦我国特色蜂蜜中特征标志物挖掘并评估其健康效应。3.多种代谢组学技术联用解析膳食多酚与肠道微生物的互作机制，开展膳食多酚对糖脂代谢、动脉粥样硬化、肠道健康、酒精性肝损伤、尿路感染调控效果与机制研究。4.探讨膳食多酚在食品热加工过程中的代谢网络与健康效应。5.特色农产品精深加工产品开发。

教育经历

1989.9-1993.6: beat365体育亚洲官方网站食品科技系/食品科学专业，获工学学士学位
1998.9-2004.6: beat365体育亚洲官方网站食品科技系/农产品加工及贮藏工程专业，硕博连读获工学博士学位

工作经历

1993.7-1998.8: beat365体育亚洲官方网站食品科技系从事学生管理工作
1998.9-2004.6: beat365体育亚洲官方网站食品科技系攻读博士学位
2002.6——至今: beat365体育亚洲官方网站食品科技学院（系）从事教学与科研

研究领域

1. 食品功能因子与分子营养
2. 蜂产品科学（特征性成分挖掘、产品加工、营养与安全的相关理论和应用技术研究）
3. 特色农副产品精深加工与副产物高值化利用

科研项目

主持包括国家自然科学基金面上项目3项、科技部“十四五”重点研发计划-子项目、国家质检总局公益性行业科研专项-子课题、湖北省重点研发计划、湖北洪山实验室重大专项-子项目，湖北省成果转化项目，武汉市应用基础前沿项目、恩施州创新团队等，及企业合作项目。近年来主持的国家及部分省市项目如下：
人才项目：
1.武汉市委组织部第五批“黄鹤英才计划”.2017-2020.
食品功能因子与营养健康领域：
2.国家自然科学基金面上项目.黄烷-3-醇低聚体的肠道菌群代谢组学及其特定代谢产物调节肝脏脂质代谢异常的作用机理研究. 2023-2026.
3.国家自然科学基金面上项目.原花青素对膳食中丙烯酰胺及其诱导细胞毒性的抑制效果与作用机制.2017-2020.
4.国家自然科学基金面上项目.高粱原花青素营养补充剂对口腔致龋齿菌粘附的干预及分子机制.2013-2016.
5.湖北洪山实验室重大项目——子项目.黑米健康价值的发掘和利用.2022-2024.
6.中国农科院深圳基因组所合作资金资助项目.新型黑米的营养与食味品质研究及改善糖脂代谢的健康效应.2023-2025.
蜂产品科学领域：
7.国家十四五重点研发计划——子课题.中蜂产品高值利用关键技术研发与新产品创制. 2022-2025.
8.湖北省重点研发计划.蜂花粉的生物破壁技术及其产品研发.2022-2024.
9.湖北省农业科技成果转化资金.复方水飞蓟蜂蜜花粉系列产品的中试与示范. 2020-2021.
10.武汉市应用基础前沿项目.蜂花粉生物工程转化及其保护肠道健康的高值化利用研究. 2020-2022.
11.武汉市农委项目.武汉市现代都市农业产业技术体系——蜂产业岗位， 2018.
12.武汉市科技平台项目.武汉市蜂产品质量控制工程技术研究中心.2009-.
13.武汉市应用基础研究计划项目.一种新型蜂产品的功能营养成分分析与活性评价。2015-2016.
特色农副产品精深加工与副产物高值化利用领域：
14.湖北省重点研发计划（乡村振兴科技支撑项目）—子项目.薹用蔬菜品质评价及高值化利用技术研发. 2022-2023.
15.湖北省重点研发计划（企业创新发展项目）—子项目.神农架特色浆果精深加工技术创新与产品研发. 2021-2023.
16.武汉市农科院重大创新项目——子项目.薹用蔬菜品质鉴定技术及高附加值产品开发.2022-2022.
17.湖北省科技厅.湖北省校企共建枸杞研发中心. 2017-2019.
18.恩施州重点创新团队.枸杞母本园及加工产品质量控制体系的建设.2015-2017.
19.湖北省科技厅高新技术产业发展专项.富硒枸杞浆果加工技术研究与示范. 2015-2016.
国家质检总局公益性行业科研专项——子项目，纯果汁检验鉴定技术研究. 2012-2014.

成果奖励

[获奖情况]
1. 作为主要完成人鉴定成果6项；制定地方标准3项。
2. 曾荣获教育部科技进步一等奖和湖北省科技进步二等奖各1项；以及“中国粮油学会第二届全国粮油优秀科技工作者”；“武汉市优秀科技特派员” ；“学校社会服务工作先进个人”等荣誉称号。
2. 先后19次被评为“省优硕士学位论文”、“省优学士学位论文”、“校优秀硕士学位论文”、校“创新论文”和大学生学科竞赛等省级奖励和国家级奖励指导教师。
3. 获得包括教学质量一等奖在内的教学质量奖、成果奖和管理奖7次。
4. 曾荣获研究生指导教师‘教书育人奖’荣誉称号。
[主要专利]
作为第一发明人的发明专利（申请发明专利20项，授权13项）：
1.高粱原花青素混合物的制备方法及其抗龋齿应用（授权）.
2.一种从高粱外种皮中提取原花青素四聚体的制备方法及应用（授权）.
3.一种检测葡萄汁中多种有机酸的含量及其真伪的方法（授权）.
4.一种佛掌山药速溶饮料的制备方法（授权）.
5.一种低热量藠头面包及其制备方法（授权）.
6.一种巢蜜舒咽喷雾剂及其制备方法（授权）.
7.一种高膳食纤维全藕粉的制备方法（申请）.
8.一种雄蜂蛹小分子抗氧化肽的制备方法及其雄蜂蛹小分子抗氧化肽的应用（申请）.
9.一种复方花粉膏干粉及其制备方法和应用（申请）.
10.一种复方花粉膏丸及其制备方法（授权）.
11.一种含枸杞酒渣的酥性饼干及其制备方法（申请）.
12.杨树芽提取物在制备脂肪氧合酶抑制剂中的用途（授权）.
13.一株从蜂粮中分离的枯草芽孢杆菌及其应用（授权）.
14.一株巴士链球菌及其在生物合成儿茶素衍生物中的应用（授权）.
15.杨树芽提取物作为饲料添加剂的用途及相应饲料（申请）.
16.一种微生物发酵制备蜂蛹抗氧化肽的方法（申请）.
17.一种油菜薹干制加工的工艺方法（申请）.
一种蒸谷黑米加工方法（申请）.
[代表性论文]
在FOOD CHEM、FOOD FUNCT、FOOD RES INT、FOOD SCI HUM WELL、INT J BIOL MACROMOL、食品科学、中国食品学报、质谱学报、农业工程学报等期刊上发表研究论文100多篇。近年来（作为通讯作者被SCI和EI收录）部分文章如下：
1.Xin Wu, Xingxing Zhang, Min Liu, Yi Zhou, Qun Lu, Tang Tang，Rui Liu*. Widely targeted metabolomics provides insights into the effect of parboiling treatment on metabolite profiles of black rice and cooked black rice. Journal of Cereal Science. 2023,114,103810.
2.Li Zhao, Xingxing Zhang, Langzhi He, Yubing Li, Yue Yu, Qun Lu, Rui Liu*. Diet with high content of advanced glycation end products induces oxidative stress damage and systemic inflammation in experimental mice: Protective effect of peanut skin procyanidins. Food Science and Human Wellness.2023.12online
3.Li Wang† , Ruonan Liu† , Fangfang Yan , Wanbing Chen , Mo Zhang , Qun Lu , Bijun Huang and Rui Liu*. A newly isolated intestinal bacterium involved in C-ring cleavage of flavan-3-ol monomers and antioxidant activity of the metabolites. Food & Function. 2024,15, 580-590.
4.Min Liu, Jinxin Shen, Xiaoling Zhu, Tingting Ju, Benjamin P. Willing, Xin Wu, Qun Lu, Rui Liu*. Peanut skin procyanidins reduce intestinal glucose transport protein expression, regulate serum metabolites and ameliorate hyperglycemia in diabetic mice. Food Research International. 2023,113471.
5.Xin Wu, Yi Zhou, Qun Lu, Rui Liu*. Ultrasonic-assisted immersion of parboiled treatment improves head rice yield and nutrition of black rice and provides a softer texture of cooked black rice. Ultrasonics Sonochemistry. 2023,95,106378.
6.Mingjuan Xu, Cheng Lv, Qun Lu, Rui Liu*.Oligomeric procyanidins combined with Parabacteroides distasonis ameliorates high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation reaction and bile acid metabolism in ApoE-/- mice. Food Science and Human Wellness.2023.3.13accepted.
7.Fangfang Yan, Li Wang, Li Zhao, Chengming Wang, Qun Lu, Rui Liu *. Acrylamide in food: Occurrence, metabolism, molecular toxicity mechanism and detoxification by phytochemicals. Food and chemical toxicology. 2023,113696.
8.Fangfang Yan, Qun Lu, Chengming Wang*, Rui Liu*. Procyanidin A1 and its digestive products alleviate acrylamide-induced IPEC-J2 cell damage through MAPKs and Nrf2 pathways. Food Science and Human Wellness. 2024,13:1475-1484.
9.Wanbing Chen#, Ruonan Liu#, Xiaoling Zhu, Li Zhang, Qun Lu, Hong Yang, Rui Liu*. Microbial phenolic metabolites 3-(3′,4′-dihydroxyphenyl)propionic acid and 3′,4′-dihydroxyphenylacetic acid prevent obesity in mice fed high-fat diet. Food Science and Human Wellness. 2024, 13(1): 327-338.
10.Min Liu, Li Wang, Bijun Huang, Qun Lu, Rui Liu*. 3,4-Dihydroxyphenylacetic acid ameliorates gut barrier dysfunction via regulation of MAPK-MLCK pathway in type 2 diabetes mice. Life Sciences. 2022,305,120742.
11.Li Zhao, Fangfang Yan, Qun Lu, Cuie Tang, Xiaohong Wang*,Rui Liu*. Q-TOF LC/MS and NMR identification of structurally different A-type procyanidins from peanut skin and their inhibitory activities on acrylamide. Journal of the Science of Food and Agriculture. 2022.102:7062-7071.
12.Min Liu, Bijun Huang, Li Wang, Qun Lu, Rui Liu*.Peanut Skin Procyanidins Ameliorates Insulin resistance via Modulation of Gut Microbiota and Gut Barrier in Type 2 Diabetic Mice. Journal of the Science of Food and Agriculture. 2022, 102(13):5935-5947.
13.Li Zhao, Xiue Jin, Yubing Li, YueYu, Langzhi He, Rui Liu*. Effects of A-type oligomer procyanidins on protein glycation using two glycation models coupled with spectroscopy, chromatography, and molecular docking. Food Research International. 2022,155,111068.
14.Bijun Huang, Li Wang, Min Liu, Xin Wu,Qun Lu, Rui Liu*. The underlying mechanism of A-type procyanidins from peanut skin on DSS-induced ulcerative colitis mice by regulating gut microbiota and metabolism. J Food Biochemistry.2022,46(7) :e14103.
15.Mingjuan Xu, Cheng Lv, Huixia Wang, Qun Lu, Mingxia Ye, Xiaoling Zhu*, Rui Liu*. Peanut skin extract ameliorates high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation reaction and gut microbiota in ApoE-/- mice. Food Research International. 2022,154:111014.
16.Yan Fangfang; Chen Wanbing; Zhao Li; Lu Qun; Wang Chengming*; Liu Rui*. Procyanidin A1 and its digestive products prevent acrylamide-induced intestinal barrier dysfunction via the MAPK-mediated MLCK pathway. Food & Function, 2021, 12,11956-11965.
17.Wanbing Chen, Li Zhang, Li Zhao, Fangfang Yan, Xiaoling Zhu, Qun Lu, Rui Liu*. Metabolomic Profiles of A-Type Procyanidin Dimer and Trimer with Gut Microbiota in Vitro. Journal of Functional Foods. 2021.85,104637.
18.Li Zhao, Xiaoling Zhu, YueYu, Langzhi He, Yubing Li, Li Zhang*, Rui Liu*. Comprehensive analysis of the anti-glycation effect of peanut skin extract. Food Chemistry. 2021,362,130169.
19.Fangfang Yan, Liang Chen, Wanbing Chen, Li Zhao, Qun Lu*, Rui Liu*. Protective effect of procyanidin A-type dimers against H2O2-induced oxidative stress in prostate DU145 cells through the MAPKs signaling pathway. Life Sciences. 2021,266,118908.
20.Fangfang Yan; Li Zhao; Wanbing Chen; Qun Lu; Chengming Wang*；Rui Liu*. Comparison of the inhibitory effects of procyanidins with different structures and their digestion products against acrylamide-induced cytotoxicity in IPEC-J2 cells. Journal of Functional Foods. 2020, 104073
21.Wanbing Chen; Xiaoling Zhu; Qun Lu; et al; Rui Liu*. C-ring cleavage metabolites of catechin and epicatechin enhanced antioxidant activities through intestinal microbiota. Food Research International. 2020, 135,109271.
22.Li Zhao, Luming Wen, Qun Lu, Rui Liu*. Interaction mechanism between α-glucosidase and A-type trimer procyanidin revealed by integrated spectroscopic analysis techniques. International Journal of Biological Macromolecules. 2020，143，173-180.
23.Li Zhao#, Ting Zhou#, Fangfang Yan, et al, Rui Liu*. Synergistic inhibitory effects of procyanidin B2 and catechin on acrylamide in food matrix. Food Chemistry. 2019, 296:94-99.
24.Li Zhao#, Fang Wang#, Qun Lu*, Rui Liu*, et al. Study on interaction between sorghum procyanidins tetramer and human salivary α-amylase: Binding characteristic and structural analysis. International Journal of Biological Macromolecules. 2018.118:1136-1141.
25.JiannanYu#, Fangfang Yan#, Qun Lu*, Rui Lui*. Interaction between sorghum procyanidin tetramers and the catalytic region of glucosyltransferases-I from streptococcus mutants UA159. Food Research International. 2018,112:152-159.
26.Xin Cai#, Jianan Yu#, Liman Xu, Rui Liu* et al. The mechanism study in the interactions of sorghum procyanidins trimer with porcine pancreatic α-amylase. Food Chemistry. 2015,174（1）：291-298.
27.刘若男，陈婉冰，等，刘睿*.基于代谢组学探究原花青素B1的肠道微生物代谢.中国食品学报(EI). 2022,9:13-23.
28.刘若男，陈婉冰，等，刘睿*.黄烷-3-醇类化合物靶向代谢组定量方法研究.质谱学报（EI）. 2022,43(1):67-77.
29.毋鑫，黄碧君，晏芳芳，等，刘睿*.黑米储藏与加工方式对其加工品质及膳食多酚影响的研究进展.食品科学(EI)，2022,43（3）：362-370.
30.刘若男，陈婉冰，晏芳芳，等，刘睿*.黄烷-3-醇类化合物吸收、代谢的特征与机制研究进展.食品科学(EI). 2021,42(21):213-222.
31.黄宁馨，鲁群，丁士勇*，刘睿*，等.主成分分析法优选枸杞乳酸菌发酵饮品发酵剂.农业工程学报(EI)，2021,37（7）:286-292.
32.赵莉，卢凯，王小红，刘睿*.花生红衣中原花青素A1的分离鉴定及其对丙烯酰胺的抑制效果.食品科学(EI).2018，39（20）:1-6.
33.Huifang Zhang; Min Liu; Fanfen Song; Xiaoling Zhu; Qun Lu*; Rui Liu*. Fermentation enhances the amelioration effect of bee pollen on Caco-2 monolayer epithelial barrier dysfunction based on NF-κB-mediated MLCK-MLC signaling pathway. Food Research International. 2024(178):113938.
34.ChengLv, MingjuanXu, Xinbiao Yang, Yanlun Feng, Yun Zhu, QunLu, Chengming Wang*, Rui Liu*.Identification of Phenolamines in Rape Bee Pollen and Its Protective Effect and Mechanism on Alcoholic Liver Injury. Food Science and Human Wellness. 2023.7.14 accepted.
35.Huifang Zhang; Xiaoling Zhu; Qian Huang; Li Zhang; Xiaohua Liu*; Qun Lu*; Rui Liu*. Antioxidant and anti-inflammatory activities of rape bee pollen after fermentation and their correlation with chemical components by ultra-performance liquid chromatography-quadrupole time of flight mass spectrometry-based untargeted metabolomics. Food Chemistry. 2023,409,135342.
36.Huifang Zhang; Qun Lu*; Rui Liu*. Widely targeted metabolomics analysis reveals the effect of fermentation on the chemical composition of bee pollen. Food Chemistry, 2022，375, 131908.
37.Yue Ding#, Mingjuan Xu#, Qun Lu, et al, Rui Liu*. Combination of Honey with Metformin Enhances Glucose Metabolism and Meliorates Hepatic and Nephritic Dysfunction in STZ-Induced Diabetic Mice. Food & Function.2019,10,7576-7587.
38.Shiqin Peng#, Ping Wei#, Qun Lu*, Rui Liu* et al. Beneficial effects of poplar buds on hyperglycemia, dyslipidemia, oxidative stress and inflammation in streptozotocin-induced type 2 diabetes. Journal of Immunology Research. 2018，Article ID 7245956.

其它

1.主持和作为核心成员参加包括“国家特色专业”、“省级一流本科课程”、“省级精品课程”、“省级教学团队”、“百门精品实践课程”和“研究生精品示范课”、“研究生联合培养实践基地”等教改和教研项目20项。参加国家精品课程配套教材《食品分析》的编写，科学出版社。
2.指导研究生获批“学校优硕培植计划”；指导研究生5人次获批省优和校优学位论文。
3.指导3名博士生受CSC资助在比利时根特大学、加拿大阿尔伯塔大学和奥地利维也纳大学联合培养.
目前在读硕士和博士研究生20多人，欢迎具有蜂产品科学、分子营养、代谢组学、合成生物学、高分辨质谱和NMR分析等背景和兴趣的莘莘学子加入实验室!